Scalable Technologies For Illuminating The Druggable Gpcr-ome
Bryan Roth, M.D., Ph.D.
Michael Hooker Distinguished Professor of Protein Therapeutics and Translational Proteomics
Department of Pharmacology
School of Medicine
University of North Carolina, Chapel Hill
- Brian Shoichet, Ph.D.
Professor Department of Pharmaceutical Chemistry
University of California, San Francisco
Collaborative work by Dr. Bryan Roth and Dr. Brian Shoichet focuses on illuminating the druggable GPCR-ome by two-pronged approach of empirical screening of drugs followed by computational screening against modeled structures of the GPCR to produced optimized lead compounds. Their work has led to discovery of molecule “ogerin” binding previously orphaned, GPR68.