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Physical Exam Of Human Neurons To Identify Functions Of The Druggable Genome

  • Steve Finkbeiner, M.D., Ph.D.
    Senior Investigator and Associate Director, Gladstone Institute of Neurological Disease
    Professor of Neurology and Physiology, University of California, San Francisco
    Director, Taube/Koret Center for Neurodegenerative Disease Research
    Director, Hellman Family Foundation Program in Alzheimer's Disease Research

  • Gaia Skibinski, Ph.D.
    Postdoctoral fellow

Overview

Advances in robotic microscopy have lead Dr. Steve Finkbeiner’s group to develop physical exams of the human neurons by longitudinal tracking of neuron signaling and differentiation with the application and development of different fluorescent tags and markers. Validation of a variety of biosensors and fluorescent signals for assays have been completed and is being applied for identification of functional responses on orphan GPCRs.

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Links

Publications

Go to Finkbeiner Publications on PubMed

Finkbeiner S., Frumkin M., Kassner PD, Cell-Based Screening: Extracting Meaning from Complex Data, Neuron 2015 Apr 8;86(1):160-174.  doi:10.1016/j.neuron.2015.02.023. PubMed Abstract: http://www.ncbi.nlm.nih.gov
/pubmed/25856492

Barmada SJ, Serio A, Arjun A, Bilican B, Daub A, Ando DM, Tsvetkov A, Pleiss M, Li X, Peisach D, Shaw C, Chandran S, Finkbeiner S. Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models. Nat Chem Biol. 2014 Aug;10(8):677-85. PubMed Abstract: http://www.ncbi.nlm .nih.gov
/pubmed/24974230
; PubMed Central PMCID: PMC4106236.

Finkbeiner S, Frumkin M, Kassner PD. Cell-based screening: extracting meaning from complex data. Neuron. 2015 Apr 8;86(1):160-74. PubMed Abstract: http://www .ncbi.nlm.nih.gov
/pubmed/25856492
; PubMed Central PMCID: PMC4457442.

Shaby BA, Skibinski G, Ando M, LaDow ES, Finkbeiner S. A three-groups model for high-throughput survival screens. Biometrics. 2016 Jan 28;PubMed Abstract: http://www.ncbi.nlm .nih.gov
/pubmed/26821783
; NIHMSID: 757531.


Genes Under investigation, Gaia Skibinski, Ph.D.

Submitted 4/22/2016

Contact Gaia Skibinski


Pharos link back: http://targetcentral.ws/TechDev6#pharos
Spec. Document

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